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If homocysteine were a true causal contributor to this process, the time required to show a beneficial intervention effect of lowering homocysteine could take much longer than the T polymorphism of the methylenetetrahydrofolate reductase ( MTHFR ) gene.51 Approximately 10% of the population are homozygous for this genetic variant and could benefit from riboflavin supplementation.52,53 An alternative therapy is supplementation with methylated folic acid, the active form of folate